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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Mechanisms of artralgia in targeted therapies for cancer
 Mráčková, Monika ; Büchler, Tomáš (advisor) ; Šírová, Milada (referee)
Many targeted anti-tumor therapies result in arthralgia, the non-inflammatory joint pain. The mechanism of pain signaling in arthralgia is not entirely understood but many studies lead to a conclusion that inflammatory cytokines play an important role. Especially interleukin (IL)-6 has been detected in high levels in plasma of patients treated with anti-vascular endothelial growth factor (anti-VEGF) therapy. Although IL-6 seems to be the key factor causing arthralgia, other possible mechanisms have been described. This review focuses on the published data about the correlation between cytokines and cancer-related arthralgia. Possible treatments and future directions are also described.
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Lymeská borrelióza - multisystémové onemocnění - víceoborová spolupráce
Dejmková, Helena ; Revmatologický ústav
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